diff --git a/src/cloudai/workloads/megatron_run/megatron_run.py b/src/cloudai/workloads/megatron_run/megatron_run.py
index e5e530f24..2216c3e86 100644
--- a/src/cloudai/workloads/megatron_run/megatron_run.py
+++ b/src/cloudai/workloads/megatron_run/megatron_run.py
@@ -39,6 +39,10 @@ class MegatronRunCmdArgs(CmdArgs):
 
     docker_image_url: str = Field()
     run_script: Path = Field()
+    command_prefix: str = Field(
+        default="",
+        description="Optional command prefix inserted before the MegatronRun python command.",
+    )
 
     global_batch_size: Optional[int] = 16
     hidden_size: Optional[int] = 4096
@@ -86,7 +90,7 @@ def cmd_args(self) -> dict[str, Any]:
             "recompute_activations"
         }
         extra_keys = set(self.model_extra or {})
-        args = self.model_dump(exclude_none=True, exclude={"docker_image_url", "run_script"})
+        args = self.model_dump(exclude_none=True, exclude={"docker_image_url", "run_script", "command_prefix"})
         result: dict[str, Any] = {}
         for k, v in args.items():
             flag = f"--{k.replace('_', '-')}"
diff --git a/src/cloudai/workloads/megatron_run/slurm_command_gen_strategy.py b/src/cloudai/workloads/megatron_run/slurm_command_gen_strategy.py
index f9f2d006f..0a49112ca 100644
--- a/src/cloudai/workloads/megatron_run/slurm_command_gen_strategy.py
+++ b/src/cloudai/workloads/megatron_run/slurm_command_gen_strategy.py
@@ -36,6 +36,7 @@ def generate_test_command(self) -> list[str]:
         tdef: MegatronRunTestDefinition = cast(MegatronRunTestDefinition, self.test_run.test)
 
         command = [
+            *([tdef.cmd_args.command_prefix] if tdef.cmd_args.command_prefix else []),
             "python",
             str((tdef.cmd_args.run_script).absolute()),
             *[f"{k} {v}" for k, v in tdef.cmd_args_dict.items()],
diff --git a/tests/workloads/megatron_run/test_command_gen_strategy_slurm.py b/tests/workloads/megatron_run/test_command_gen_strategy_slurm.py
new file mode 100644
index 000000000..af10fb39c
--- /dev/null
+++ b/tests/workloads/megatron_run/test_command_gen_strategy_slurm.py
@@ -0,0 +1,61 @@
+# SPDX-FileCopyrightText: NVIDIA CORPORATION & AFFILIATES
+# Copyright (c) 2026 NVIDIA CORPORATION & AFFILIATES. All rights reserved.
+# SPDX-License-Identifier: Apache-2.0
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#     http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+from pathlib import Path
+
+from cloudai import TestRun
+from cloudai.systems.slurm import SlurmSystem
+from cloudai.workloads.megatron_run import (
+    MegatronRunCmdArgs,
+    MegatronRunSlurmCommandGenStrategy,
+    MegatronRunTestDefinition,
+)
+
+
+def _megatron_run_test_run(tmp_path: Path, command_prefix: str = "") -> TestRun:
+    tdef = MegatronRunTestDefinition(
+        name="megatron-run",
+        description="MegatronRun",
+        test_template_name="MegatronRun",
+        cmd_args=MegatronRunCmdArgs(
+            docker_image_url="fake://url/mr",
+            run_script=tmp_path / "pretrain.py",
+            command_prefix=command_prefix,
+        ),
+    )
+    return TestRun(name="megatron-run", test=tdef, num_nodes=1, nodes=[], output_path=tmp_path)
+
+
+def test_megatron_run_command_has_no_prefix_by_default(slurm_system: SlurmSystem, tmp_path: Path) -> None:
+    tr = _megatron_run_test_run(tmp_path)
+    cmd_gen = MegatronRunSlurmCommandGenStrategy(slurm_system, tr)
+
+    command = cmd_gen.generate_test_command()
+
+    assert command[0] == "python"
+    assert "--command-prefix" not in " ".join(command)
+
+
+def test_megatron_run_command_prefix_wraps_python_command(slurm_system: SlurmSystem, tmp_path: Path) -> None:
+    tr = _megatron_run_test_run(tmp_path, command_prefix="/cloudai_install/bindpcie --")
+    cmd_gen = MegatronRunSlurmCommandGenStrategy(slurm_system, tr)
+
+    command = cmd_gen.generate_test_command()
+    srun_command = cmd_gen.gen_srun_command()
+
+    assert command[:2] == ["/cloudai_install/bindpcie --", "python"]
+    assert "--command-prefix" not in " ".join(command)
+    assert "/cloudai_install/bindpcie -- python " in srun_command