diff --git a/.changeset/pretty-mangos-itch.md b/.changeset/pretty-mangos-itch.md
new file mode 100644
index 0000000..6f75d0d
--- /dev/null
+++ b/.changeset/pretty-mangos-itch.md
@@ -0,0 +1,5 @@
+---
+"evervault-python": patch
+---
+
+Widen cryptography dependency version constraint to allow 50.x.
diff --git a/poetry.lock b/poetry.lock
index b60b14d..d5bece2 100644
--- a/poetry.lock
+++ b/poetry.lock
@@ -1037,4 +1037,4 @@ zstd = ["backports-zstd (>=1.0.0) ; python_version < \"3.14\""]
 [metadata]
 lock-version = "2.1"
 python-versions = "^3.10.0"
-content-hash = "7730578aedbd494bf3178942ce49f1540474fd3030d3e87600a6ea1ae314b3f6"
+content-hash = "cbb4ae62b751ab3a203a8e12b798859077e71f03545d848e703671f8cf20607e"
diff --git a/pyproject.toml b/pyproject.toml
index b8f508f..448dc7a 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -11,7 +11,7 @@ repository = "https://github.com/evervault/evervault-python"
 [tool.poetry.dependencies]
 python = "^3.10.0"
 requests = "^2.32.4"
-cryptography = ">=46.0.6,<50"
+cryptography = ">=46.0.6,<51"
 certifi = "*"
 pycryptodome = "^3.10.1"
 pyasn1 = "^0.6.4"