Wreath framework manuscript code

This repository contains the code used to generate results in the manuscript: "A framework for genome-wide characterization of DNA methylation and variant effect prediction".

Overview

The repository is organized by analysis, with each directory corresponding to a specific figure or set of results:

• MeC_clustering: Genome-wide annotation of the 5mC methylation landscape (Fig. 2)
• gwas_ldsr: Partitioning heritability using methylation classes (Fig. 3)
• mqtl_effect_sizes: Prediction of mQTL effects using Wreath (Fig. 5)
• pathogenic_mutations: Prediction of variant effects for disease regulatory mutations (Fig. 6)

Help and support

For questions about the repository, requests for additional data, or further information about the analyses and results, please open an issue in the GitHub repository.