SimChrom - an interactive resource to explore function, composition and localization of human chromatin proteins

The resource provides interactive tools to analyze human nuclear and chromatin proteins with respect to their subnuclear localization (based on data from UniProt, HPA, OpenCell), chromatin category according to the developed simplified chromatin protein classification (SimChrom), protein abundance (from PaxDb), and domain architecture and composition (based on Pfam and predicted in TED). Preprocessed MS-based chromatome datasets and reference sets of nuclear and non-nuclear proteins are also available for download.

SimChrom is based on the work described in: Gribkova et al., Nucleic Acids Research (2026), doi:10.1093/nar/gkaf1489.
Correspondence can be addressed to shaytanak@my.msu.ru.

https://simchrom.intbio.org/ - main page

https://simchrom.intbio.org/#localization - localization data

https://simchrom.intbio.org/#classification - SimChrom chromatin proteins classification

https://simchrom.intbio.org/#download - reference datasets downloads

https://simchrom.intbio.org/#novel_structural_domains - Novel 3D structural domains

https://simchrom.intbio.org/#domain_composition - Analysis of Pfam domain composition

https://simchrom.intbio.org/#domain_co-occurrence - Analysis of Pfam domain co-occurence